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K. Mamba, E. Sagara, and A. Uchiumi
[Biomedical Rch. On Trace Elements, Vol.4, No.2, pp.169-170, 1993]
The effect of zinc deficiency on trace elements in the liver, spleen and kidney was investigated in the control and zinc-deficient adult male jirds. The contents of zinc, iron, copper, calcium, magnesium, manganese and potassium in the tissue were measured ICP emission spectrometry. The content of manganese was significantly low in the liver and kidney of the deficient group in comparison with that in the control group. The contents of other elements showed no significant difference in every tissue examined between control and deficient group. Ultrastructurally, the liver of control jirds showed the appearance of vacuoles with various sizes and increase of small oval sER. But the liver of zinc-deficient jirds showed the appearance of well-developed rER, sER and increase of mitochondria. These findings suggest that zinc deficiency causes the decrease of manganese in the liver and kidney (Table 1), and that there is an intimate interrelationship between zinc and manganese in the metabolism of manganese and no effect on other elements.
