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T. Shimizu and M. Hato
[Biochimica et Biophysica Acta, Vol.1147, pp.50-58, 1993]
Novel peptidic lipids were synthesized by the coupling of a linear oligopeptide as the hydrophilic moiety with a glutamic acid dialkylamide as the hydrophobic moiety. Their self-assembling properties were investigated. The critical aggregate concentrations (CAC) for the peptidic lipids with a double dodecyl group were in the range of 1.0 · ^{-5}- 3.8 · ^{-5} M. The phase transition parameters and the aggregation morphologies in aqueous dispersion were largely dependent on the number and nature of the constitutive amino acid residues. Dark-field optical microscopy demonstrated that the present peptidic lipids can form four types of stable morphologies in water, i.e., tubular structures (Fig.1), twisted ribbons, vesicles, and amorphous crystals.
