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Biocompatibility of Polymethionine Membranes and Their Oxidized Membranes as Wound-covering Materials

Yukihiko FUJIWARA, sei-ichi AIBA, Norihiko MINOURA, Kokoro IIO and Yukihide TSUCHIDA
J. of NIMC. Vol.6, No.6, pp.275-282(1998)

Poly( L-methionine ) and poly( D-methionine ) were synthesized and casted to make membranes. Oxidized membranes of the polymers were also prepared. These membranes were implanted subcutaneously in rats. The biocompatibility of the polymer membranes was evaluated by observing microscopically the tissue reaction, and by measuring the change in weight of implanting samples. Tissue reaction of the oxidized polymethionine membranes were lower than those of the polymethionine membranes as regards cells infiltration, adherence and thickness of fibrocellular capsule. D-form membranes were not biodegradable, and the weight of the membranes increased. The oxidized poly(L-methionine) membrane had good biocompatibility as wound-covering materials.

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